YTGT: A new high-prevalence antigen in the Yt blood group system in two unrelated Native Americans and transfusion management.

Nancy L van BurenBarbara GillenChristine Lomas-FrancisAnna BurgosDaniel PeaseMaria BeaverAdam ImbrykJulia DuggerAlexandra FugateEric HebelMichelle LodermeierSunitha Vege Connie M Westhoff

Published in: Transfusion (2022)

Two unrelated NA patients were found to have an antibody to a new high-prevalence Yt antigen, designated YTGT (YT6), associated with a clinically significant transfusion reaction. Identification of the specificity relied on enzyme sensitivity, use of PNH-III RBCs, neutralization using soluble recombinant Yt, and the finding of a novel change in ACHE, c.290A>G (p.Gln97Arg), designated YT*01.-06. IVIG and steroids were used to mitigate further reactions to transfusion.

Keyphrases

cardiac surgery
risk factors
end stage renal disease
sickle cell disease
ejection fraction
newly diagnosed
prognostic factors
cord blood
acute kidney injury
patient reported outcomes
cell free