Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients.

Andrew E ArrantSkylar E DavisRachael M VollmerCharles F MurchisonJames A MobleyAlissa L NanaSalvatore SpinaLea T GrinbergAnna M KarydasBruce L MillerWilliam W SeeleyErik D Roberson

Published in: Annals of clinical and translational neurology (2020)

These data show that symptomatic FTD-GRN patients have elevated levels of brain and plasma EVs, and that this effect is modeled in the brain of Grn-/- mice after the onset of pathology. This increase in EVs could influence FTD disease progression, and provides further support for EVs as potential FTD biomarkers.

Keyphrases

end stage renal disease
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ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
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multiple sclerosis
machine learning
risk assessment
patient reported outcomes
climate change
brain injury
big data
deep learning