Lewis acid mediated cyclization: synthesis of 2 spirocyclohexylindolines.

Xiang-Kai KongZhi-Min XiongXiang ZhiXue-Ling MengJing-Feng ZhaoWen ChenHong-Bin Zhang

Published in: Organic & biomolecular chemistry (2022)

Herein, we report the synthesis of 2-spirocyclohexylindolines based on a Lewis acid mediated cyclization. This diastereoselective procedure provides the target structures in a straightforward way via dual activation.

Keyphrases

high resolution
minimally invasive
mass spectrometry