Chronic Kidney Disease Is Characterized by Expansion of a Distinct Proinflammatory Intermediate Monocyte Subtype and by Increased Monocyte Adhesion to Endothelial Cells.

Sarah CormicanNeema NegiSerika D NaickerMd Nahidul IslamBarbara FazekasRachael PowerMatthew D GriffinM Conall DennedyBriain MacNeillAndrew F MaloneMatthew D Griffin

Published in: Journal of the American Society of Nephrology : JASN (2023)

CKD is associated with an increased number of a distinctive proinflammatory IM subpopulation and abnormalities of monocyte migration and endothelial adhesion. Dysregulated monocyte maturation and function may represent targetable factors contributing to accelerated CVD in CKD.

Keyphrases

endothelial cells
chronic kidney disease
dendritic cells
end stage renal disease
high glucose
peripheral blood
vascular endothelial growth factor
biofilm formation
immune response
escherichia coli
pseudomonas aeruginosa