Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade.

Ying ZhuJing YangDa XuXiao-Mei GaoZe ZhangJennifer L HsuChia-Wei LiSeung-Oe LimYuan-Yuan ShengYu ZhangJian-Hua LiQin LuoYan ZhengYue ZhaoLu LuHu-Liang JiaMien-Chie HungQiong-Zhu DongLun-Xiu Qin

Published in: Gut (2019)

OPN/CSF1/CSF1R axis plays a critical role in the immunosuppressive nature of the HCC microenvironment. Blocking CSF1/CSF1R prevents TAM trafficking and thereby enhances the efficacy of immune checkpoint inhibitors for the treatment of HCC.

Keyphrases

stem cells
cerebrospinal fluid
adipose tissue
high glucose
mouse model
oxidative stress
stress induced