Understanding the Impact of Population and Cancer Type on Tumor Mutation Burden Scores: A Comprehensive Whole-Exome Study in Cancer Patients From India.
Nishtha AjitSingh TanwarRicha MalhotraAiswarya Padmaja SatheeshSatya Prakash KhuntiaPeddagangannagari SreekanthreddyLinu VargheseSrivalli KollaPratik ChandraniAnuradha ChoughulePriyanka PangeVinod GuptaVanita NoronhaVijay Maruti PatilRaja PramanikSunila KumarSandeep Peraje NayakSuresh BabuRohan ShettyMadan KantharajuPramod Shekarappa ChinderAruna KorlimarlaB S SrinathKumar PrabhashKshitij Datta RishiHitesh Madan GoswamiVidya Harini VeldorePublished in: JCO global oncology (2023)
The findings of this study indicate that it is crucial to benchmark both cancer-specific and population-specific TMB distributions to establish a TMB threshold for each cancer in various populations. Additional prospective studies on much larger population across different cancers are warranted to validate this observation to become the standard of care.