α5β1-Integrin inhibitor (CLT-28643) effective in rabbit trabeculectomy model.

Maximilian SchultheissSven SchnichelsEva-Maria KonradKarl U Bartz-SchmidtGrit ZahnPatrizia CaldirolaMario G FsadniNinus Caram-LelhamMartin S Spitzer

Published in: Acta ophthalmologica (2016)

This rabbit GFS study indicates that inhibition of α5β1-integrin by the novel α5β1-integrin antagonist CLT-28643 significantly improved the outcome. The effect of a single intro-operative application of CLT-28643 seems to be inferior to 0.04% MMC.

Keyphrases

cell adhesion
cell migration