A Novel MRI Biomarker of Spinal Cord White Matter Injury: T2*-Weighted White Matter to Gray Matter Signal Intensity Ratio.

Allan R Martin Benjamin De Leener Julien Cohen-Adad D W Cadotte Sukhvinder Kalsi-Ryan S F Lange Lindsay Tetreault Joseph S Cheng A P Crawley David John Mikulis H Ginsberg Michael G Fehlings

Published in: AJNR. American journal of neuroradiology (2017)

T2*WI WM/GM shows promise as a novel biomarker of WM injury. It detects damage in compressed and uncompressed regions and contributes substantially to multivariate models for diagnosis and correlation with impairment. Our multiparametric approach overcomes limitations of individual measures, having the potential to improve diagnostics, monitor progression, and predict outcomes.

Keyphrases

white matter
spinal cord
multiple sclerosis
contrast enhanced
magnetic resonance imaging
spinal cord injury
magnetic resonance
oxidative stress
neuropathic pain
high intensity
big data
type diabetes
diffusion weighted imaging
metabolic syndrome
weight loss
climate change
glycemic control
insulin resistance