Natural history, spectrum and outcome of stage 3 AKI in patients with acute-on-chronic liver failure.

Rakhi MaiwallArchana RastogiSamba Siva R PasupuletiAshini K HidamMansi SinghSonia KadyanPriyanka JainGuresh KumarShiv Kumar Sarin

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

AKI-3 rapidly increases from 13% to 33% within 30 days in ACLF patients. Histopathological data suggested cholemic nephropathy as the predominant cause which correlated with high bilirubin levels. AKI-3 resolves in only one in five patients. Patients with AARC grade 3 and MELD >35 demand need for early dialysis in AKI-3 for improved outcomes.

Keyphrases

end stage renal disease
acute kidney injury
chronic kidney disease
peritoneal dialysis
newly diagnosed
ejection fraction
liver failure
prognostic factors
type diabetes
hepatitis b virus
adipose tissue
patient reported outcomes
skeletal muscle
insulin resistance
deep learning
weight loss