Blood Eosinophils Are Associated with Efficacy of Targeted Therapy in Patients with Advanced Melanoma.

Simone WendlingerJonas WohlfarthSophia KreftClaudia SiedelTeresa KilianUlrich DischingerMarkus Vincent Heppt Kilian Wistuba-HamprechtFriedegund MeierMatthias Goebeler Dirk SchadendorfAnja GesierichCorinna Kosnopfel Bastian Schilling

Published in: Cancers (2022)

High pre-treatment eosinophil counts in advanced melanoma patients were associated with a significantly improved response to MAPKi. Functionally, eosinophils show potent cytotoxicity towards melanoma cells, which can be reinforced by MAPKi. Further studies are needed to unravel the molecular mechanisms of our observations.

Keyphrases

end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
peritoneal dialysis
peripheral blood
patient reported outcomes
basal cell carcinoma