A metal-organic cage-based nanoagent for enhanced photodynamic antitumor therapy.

Wen-Yan LiChao-Wei ZhaoYue-Feng ZhangQun GuanJing-Jing WanJian-Ping Ma Yan-An Li Yu-Bin Dong

Published in: Chemical communications (Cambridge, England) (2021)

Herein, we report, for the first time, a Pd6L8(NO3)5.4(ICG)6.6 (ICG = indocyanine green) cage-based hexagonal nanoplate (3) via a combined nanoprecipitation and solid-state anion-exchange approach. Nanoplate 3 possesses enhanced near-infrared (NIR) light-triggered 1O2 generation, high cellular uptake selective lysosome-targeting ability, and, consequently, excellent antineoplastic activity.

Keyphrases

solid state
fluorescence imaging
cancer therapy
fluorescent probe
photodynamic therapy
living cells
stem cells
drug release
smoking cessation