Complement factor C4a does not activate protease-activated receptor 1 (PAR1) or PAR4 on human platelets.

Published in: Research and practice in thrombosis and haemostasis (2020)

Complement factor C4a does not activate PAR1 or PAR4 on human platelets. These data show that PAR1 and PAR4 activation by C4a on microvascular cells likely requires a cofactor, which reinforces the concept of cell type-specific regulation of protease signaling.

Keyphrases

endothelial cells
induced pluripotent stem cells
induced apoptosis
signaling pathway
red blood cell
artificial intelligence
data analysis