Antenatal dexamethasone retarded fetal long bones growth and development by down-regulating of insulin-like growth factor 1 signaling in fetal rats.

Junlan QiuXiaorong FanHongmei DingMeng ZhaoTing XuJiahui LeiBingyu JiZhixiang Zhuang Qinqin Gao

Published in: Human & experimental toxicology (2022)

This study indicated that antenatal DEX treatment-retarded fetal skeletal growth was associated with the down-regulation of IGF1 signaling in growth plate chondrocytes, providing important information about the impact of antenatal DEX application four courses on premature infant.

Keyphrases

pregnant women
preterm birth
low dose
high dose
signaling pathway
binding protein
health information
extracellular matrix
combination therapy
smoking cessation