ERAP-1 and ERAP-2 Variants in Liver Injury After COVID-19 mRNA Vaccination: A US Multicenter Study.
Robert J FontanaYi Ju LiRaj K VuppalanchiDavid E KleinerJiezhun GuHersh ShroffLisa B Van WagnerPaul B Watkinsnull nullPublished in: The American journal of gastroenterology (2024)
Acute liver injury may arise within 8 weeks of COVID-19 mRNA vaccination that is generally mild and self-limited in most patients. The absence of an association with the AIH HLA alleles combined with the significant ERAP-2 and ERAP-1 Hap6 haplotype associations implicates a unique but very rare host immune response to vaccine-derived antigens in the pathogenesis of COVID-19 vaccine hepatotoxicity.
Keyphrases
- liver injury
- drug induced
- coronavirus disease
- sars cov
- end stage renal disease
- ejection fraction
- respiratory syndrome coronavirus
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- binding protein
- dendritic cells
- liver failure
- gene expression
- immune response
- hepatitis b virus
- acute respiratory distress syndrome
- preterm birth