Amphiregulin promotes hair regeneration of skin-derived precursors via the PI3K and MAPK pathways.
Qiumei LuYing GaoZhimeng FanXing XiaoYu ChenYuan SiDeqiang KongShuai WangMeijian LiaoXiaodong ChenXusheng WangWeiwei ChuPublished in: Cell proliferation (2021)
By exploiting a 3D co-culture model, we determined that AREG promoted SKP stemness by enhancing both proliferation and hair-inducing capacity through the PI3K and MAPK pathways. These findings suggest AREG therapy as a potentially promising approach for treating alopecia.