Glucagon-like Peptide-1 Receptor Agonists and Suicidal Ideation: Analysis of Real-Word Data Collected in the European Pharmacovigilance Database.

Rosanna RuggieroAnnamaria MascoloAngela SpezzaferriClaudia CarpentieriDaniele TorellaLiberata SportielloFrancesco RossiGiuseppe PaolissoAnnalisa Capuano

Published in: Pharmaceuticals (Basel, Switzerland) (2024)

Suicidal events were mostly reported with semaglutide and liraglutide, which were also associated with significantly higher reporting probabilities compared to other GLP1 RAs. Although this study provides the reporting frequencies of suicide-related events with GLP-1 RAs, establishing causality requires further investigation, which will probably be addressed by the Pharmacovigilance Risk Assessment Committee of the European Medicine Agency in the future.

Keyphrases

adverse drug
electronic health record
risk assessment
drug induced
emergency department
wild type
depressive symptoms
heavy metals
current status
big data
machine learning
drug administration