The evolutionary process of mammalian sex determination genes focusing on marsupial SRYs.
Yukako KatsuraHiroko X KondoJanelle RyanVincent HarleyYoko SattaPublished in: BMC evolutionary biology (2018)
Despite the sequence differences between the marsupial and eutherian SRY genes, our functional assay indicates that the marsupial SRY gene regulates SOX9 as a transcription factor in a similar way to the eutherian SRY gene. Our results suggest that SRY genes obtained the function of male determination in the common ancestor of Theria (placental mammals and marsupials). This suggests that the marsupial SRY gene has a function in male determination, but additional experiments are needed to be conclusive.
Keyphrases
- genome wide identification
- genome wide
- transcription factor
- copy number
- dna methylation
- genome wide analysis
- solid phase extraction
- molecularly imprinted
- stem cells
- dna binding
- high throughput
- gene expression
- mass spectrometry
- high resolution
- liquid chromatography
- simultaneous determination
- tandem mass spectrometry