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Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin.

Michael E JohnsonJennifer M FranksGuoshuai CaiBhaven K MehtaTammara A WoodKimberly ArchambaultPatricia A PioliRobert W SimmsNicole M OrzechowskiSarah T ArronMichael L Whitfield
Published in: Arthritis research & therapy (2019)
Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression. These data provide a comprehensive portrait of the SSc skin microbiome and its association with local gene expression, which mirrors the molecular changes in lesional skin.
Keyphrases
  • gene expression
  • systemic sclerosis
  • dna methylation
  • soft tissue
  • interstitial lung disease
  • wound healing
  • oxidative stress
  • rheumatoid arthritis