Maerua angolensis DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Rats.

Charles Kwaku Benneh Robert Peter BineyAugustine TandohFelix Agyei AmpaduDonatus Wewura AdongoJonathan JatoEric Woode

Published in: Evidence-based complementary and alternative medicine : eCAM (2018)

The petroleum ether/ethyl acetate fraction exhibits antiseizure activity by affecting GABAergic and nitric oxide-cGMP pathways. In addition, the extract protects against the generation of free radicals and the oxidative products of the PTZ-induced seizures.

Keyphrases

nitric oxide
hydrogen peroxide
oxidative stress
diabetic rats
high glucose
ionic liquid
nitric oxide synthase
anti inflammatory
protein kinase
temporal lobe epilepsy
endothelial cells