Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates.
Kizzmekia S CorbettBarbara FlynnKathryn E FouldsJoseph R FrancicaSeyhan Boyoglu-BarnumAnne P WernerBritta FlachSarah O'ConnellKevin W BockMahnaz MinaiBianca M NagataHanne A ElyardDavid R MartinezAmy T NoeNaomi DouekMitzi M DonaldsonNadesh N NjiGabriela S AlvaradoDarin K EdwardsDillon R FlebbeEvan LambNicole A Doria-RoseBob C LinMark K LouderSijy O'DellStephen D SchmidtEmily PhungLauren A ChangChristina YapJohn-Paul M ToddLaurent PessaintAlex Van RyShanai BrowneJack GreenhouseTammy Putman-TaylorAmanda StrasbaughTracey-Ann CampbellAnthony CookAlan DodsonKatelyn SteingrebeWei ShiYi ZhangOlubukola M AbionaLingshu WangAmarendra PeguEun Sung YangKwanyee LeungTongqing ZhouI-Ting TengAlicia WidgeIngelise GordonLaura NovikRebecca A GillespieRebecca J LoomisJuan I MolivaGuillaume Stewart-JonesSunny HimansuWing-Pui KongMartha C NasonKaitlyn M MorabitoTracy J RuckwardtJulie E LedgerwoodMartin R GaudinskiPeter D KwongJohn R MascolaAndrea CarfiMark G LewisRalph S BaricAdrian McDermottIan N MooreNancy J SullivanMario RoedererRobert A SederBarney S GrahamPublished in: The New England journal of medicine (2020)
Vaccination of nonhuman primates with mRNA-1273 induced robust SARS-CoV-2 neutralizing activity, rapid protection in the upper and lower airways, and no pathologic changes in the lung. (Funded by the National Institutes of Health and others.).