CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity.

Juan WuYueran LiShuwei TianShufang NaHongyan WeiYafei WuYafei YangZixia ShenJiayue DingShenglan BaoSiqi LiuLingyun LiRongling FengYong ZhuChunyan HeJiang Yue

Published in: CNS neuroscience & therapeutics (2024)

Brain CYP1B1 plays a critical role in both cerebrovascular and dopamine homeostasis, which might serve as a novel therapeutic target for the prevention of Mn-induced neurotoxicity.

Keyphrases

diabetic rats
oxidative stress
high glucose
drug induced
dna damage
endothelial cells
white matter
resting state
multiple sclerosis
metabolic syndrome
functional connectivity
induced apoptosis
prefrontal cortex
heat shock