The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis.

Jiangyuan GaoJing Z CuiAikun WangHao Hang Rachel ChenAlison FongJoanne Aiko Matsubara

Published in: Journal of neuroinflammation (2019)

Together, these data suggest XIAP-mediated inhibition of inflammasome activity in RPE may provide insights into the biological consequences of inflammasome activation in RPE and reveals the caspase-1/XIAP/IL-1β/IL-18 axis as a target for broader applications in AMD biology and treatment design.

Keyphrases

cell death
electronic health record
big data
induced apoptosis
combination therapy
artificial intelligence