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A Biaryl-Cyclohexenone Photoelectrocyclization/Dearomatization Sequence to Substituted Terpenes.

K S Satyanarayana TummalapalliXuchen ZhaoJon D Rainier
Published in: Tetrahedron (2022)
Described here is the development of sequential cross-coupling, photoelectrocyclizations, and reductive dearomatizations of biaryl cyclohexenones as a means of synthesizing terpene skeletons. This methodology promises to provide insight that will enable us and others to use this approach to generate a variety of biologically active small molecules, including members of the abietane and morphinan skeletons.
Keyphrases
  • molecular docking
  • amino acid
  • molecular dynamics simulations