Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPD.

Alen FaizStelios PavlidisChih-Hsi KuoAnthony RowePieter S Hiemstra Hidde J Haisma Marijn BergMarissa WismanYi-Ke GuoRatko DjukanovićPeter SterkKerstin B MeyerMartijn C NawijnIan AdcockKian Fan ChungMaarten van den Berge

Published in: Thorax (2022)

Sputum-derived transcriptomic signatures from an asthma cohort can be recapitulated in bronchial biopsies of patients with COPD and identified a signature of airway mast cells as a predictor of corticosteroid responsiveness.

Keyphrases

chronic obstructive pulmonary disease
lung function
genome wide
cystic fibrosis
air pollution
mycobacterium tuberculosis
copy number
dna methylation
pulmonary tuberculosis
allergic rhinitis
gene expression
genome wide identification
transcription factor