Bone Fracture Enhanced Blood-Brain Barrier Breakdown in the Hippocampus and White Matter Damage of Stroke Mice.
Jinhao HuangHaiyan LyuKang HuoLeandro B Do PradoChaoliang TangZhanqiang WangQifeng LiJulia WongHua SuPublished in: International journal of molecular sciences (2020)
BF exacerbates neuroinflammation and BBB leakage in the hippocampus and WM damage in basal ganglia, which could contribute to the long-lasting memory dysfunction in BF+stroke mice.
Keyphrases
- blood brain barrier
- cerebral ischemia
- oxidative stress
- white matter
- high fat diet induced
- atrial fibrillation
- subarachnoid hemorrhage
- cognitive impairment
- bone mineral density
- working memory
- multiple sclerosis
- traumatic brain injury
- soft tissue
- inflammatory response
- lipopolysaccharide induced
- body composition
- postmenopausal women
- hip fracture
- bone loss
- prefrontal cortex