Identification of isoaspartate-modified transthyretin as potential target for selective immunotherapy of transthyretin amyloidosis.
Janett KöppenMartin KleinschmidtMarkus MorawskiJens-Ulrich RahfeldMichael WermannHolger CynisUte HegenbartChristoph DanielSteffen RoßnerStephan SchillingAnja SchulzePublished in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2024)
These antibodies label aged, non-native TTR deposits, leaving native TTR unattended and thereby potentially enabling new therapeutic approaches.
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