Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease.

Francesco De ChiaraKaren Louise ThomsenAbeba HabtesionHelen JonesNathan DaviesJordi Gracia-SanchoNicolò ManicardiAndrew HallFausto AndreolaHannah L PaishLee H ReedAbigail A WatsonJack LeslieFiona OakleyKrista RomboutsRajeshwar Prosad MookerjeeJelena MannRajiv Jalan

Published in: Hepatology (Baltimore, Md.) (2019)

The results of this study suggest that hepatic steatosis results in hyperammonemia, which is associated with progression of hepatic fibrosis. Reduction of ammonia levels prevented progression of fibrosis, providing a potential treatment for NAFLD.

Keyphrases

liver fibrosis
room temperature
anaerobic digestion
risk assessment
climate change
replacement therapy