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Interactions between Yersinia pestis V-antigen (LcrV) and human Toll-like receptor 2 (TLR2) in a modelled protein complex and potential mechanistic insights.

Tiandi WeiJing GongGuojing QuMingyu WangHai Xu
Published in: BMC immunology (2019)
A heterotetrameric structure of Y. pestis LcrV and human TLR2 was modelled in this work. Analysis of this modelled structure showed its stability in aquatic environments and the role of LcrV domains and residues in protein-protein interaction. A mechanistic model for the role of LcrV in Y. pestis pathogenesis is raised based on this heterotetrameric structure model. This work provides a hypothesis of LcrV function, with which further experimental validation may elucidate the role of LcrV in human immune response repression.
Keyphrases
  • toll like receptor
  • immune response
  • endothelial cells
  • protein protein
  • inflammatory response
  • nuclear factor
  • induced pluripotent stem cells
  • risk assessment
  • dendritic cells
  • climate change