Stoichioproteomics reveal oxygen usage bias, key proteins and pathways in glioma.
Yongqin YinBo LiKejie MouMuhammad T KhanAman C KaushikDongqing WeiYu-Juan ZhangPublished in: BMC medical genomics (2019)
Element signature of oxygen limitation could not be detected in glioma, just as what happened in plants and microbes. Unsaved use of oxygen by the highly expressed proteins and DEPs were adapted to the fast division of glioma cells. This study can help to reveal the molecular mechanism of glioma, and provide a new approach for studies of cancer-related biomacromolecules. In addition, this study lays a foundation for application of stoichioproteomics in precision medicine.
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