Effect of Excessive Serotonin on Pharmacokinetics of Cephalexin after Oral Administration: Studies with Serotonin-Excessive Model Rats.
Shun NakashimaTakeharu IwamotoMasashi TakanashiKen-Ichi OgawaraMasato MaruyamaKazutaka HigakiPublished in: Pharmaceutical research (2022)
5-HT-excessive condition enhanced the oral bioavailability of CEX in rats, which would be attributed to the enhanced permeability across the intestinal mucosa via passive diffusion through the paracellular route even though the transport via PEPT1 was decreased.