Isolation and In silico Study of Curcumin from Curcuma longa and Its Anti-Diabetic Activity.

Natural products have been widely used for the management of various diseases that affect human health. Natural products are chemical substances that can be extracted with solvents and isolated by column chromatography techniques from the plant source. The development of new drugs from natural products is still challenging, and the most extensively studied plant material is turmeric, Curcuma longa, which is the chief source of curcumin. Curcumin is a bright yellow solid. In our present study, we have taken Curcuma longa, which is defatted with hexane, followed by being extracted with methanol as a solvent. The turmeric methanolic extract is taken for the isolation of curcumin. This was carried out and confirmed by spectroscopy techniques including 1 H NMR, 13 C NMR, ESI-HRMS, and FT-IR. The compound in silico ADME properties estimate falls within an acceptable range, and a molecular docking analysis shows that it has a higher binding affinity than reference standards. Based on the findings, it can be said that curcumin, a natural substance, has good therapeutic qualities when it is isolated.