Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrier.
Namho KimGijung KwakJason RodriguezAlessandra Livraghi-ButricoXinyuan ZuoValentina SimonEric HanSiddharth Kaup ShenoyNikhil PandeyMarina MazurSusan E BirketAnthony KimSteven M RoweRichard BoucherJustin HanesJung Soo SukPublished in: Thorax (2021)
DNA-MPP constitutes one of the rare gene delivery systems providing therapeutically meaningful gene transfer efficacy in highly relevant in vivo and in vitro models of muco-obstructive lung diseases due to its unique ability to efficiently penetrate airway mucus.