No seroconversion in a retrospective study analyzing QuantiFERON TB-gold testing in pediatric psoriasis and hidradenitis suppurativa patients taking biologic therapy at an academic center in New York City.
Apostolos KatsiaunisJade ConwayShari R LipnerPublished in: Pediatric dermatology (2024)
Guidelines are inconsistent regarding annual QuantiFERON® TB Gold (QFT) tests in children taking biologics for dermatological conditions, and there is limited research on seroconversion, especially in regions with high tuberculosis (TB) prevalence. A retrospective review of pediatric patients taking biologic treatment for psoriasis or hidradenitis suppurativa (HS) who had one baseline and at least one follow-up QFT test was conducted to assess for seroconversion during treatment. Thirty-two patients were included, with no instances of seroconversion. These findings suggest that routine annual TB rescreening for pediatric patients taking biologic therapy for dermatologic conditions may not be necessary without additional TB exposure risks or symptomatology.
Keyphrases
- mycobacterium tuberculosis
- end stage renal disease
- hidradenitis suppurativa
- rheumatoid arthritis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- stem cells
- mesenchymal stem cells
- patient reported outcomes
- human immunodeficiency virus
- hiv infected
- pulmonary tuberculosis
- hepatitis c virus
- combination therapy
- smoking cessation
- antiretroviral therapy