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mSphere of Influence: How host genetics impact microbial pathogenesis and treatment of infectious disease.

Emily E Rosowski
Published in: mSphere (2023)
Emily Rosowski works in the field of host-pathogen interactions, studying how host innate immune mechanisms control pathogens. In this mSphere of Influence article, she reflects on how "Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections" by D. M. Tobin, F. J. Roca, S. F. Oh, R. McFarland, et al. (Cell 148:434-446, 2012, https://doi.org/10.1016/j.cell.2011.12.023) made an impact on her by investigating how differences in host genetics can affect modes of microbial pathogenesis and inform treatments for infectious disease.
Keyphrases
  • infectious diseases
  • innate immune
  • single cell
  • microbial community
  • cell therapy
  • mycobacterium tuberculosis
  • oxidative stress
  • bone marrow
  • mesenchymal stem cells
  • gram negative
  • replacement therapy