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Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis.

Mrigya BabutaCaroline MorelMarcelle de Carvalho RibeiroCharles CalendaMartí Ortega-RiberaPrashanth Thevkar NageshChristopher CopelandYuan ZhuangYanbo WangYeonhee ChoRadhika JoshiViliam BrezaniDanielle HawrylukAditi Ashish DattaJeeval MehtaImad NasserGyongyi Szabo
Published in: Gut (2024)
Alcohol binges promote liver fibrosis via NET-induced activation of HSCs and monocytes in MASH. Our study highlights the potential of inhibition of NETs and/or NLRP3, as novel therapeutic strategies to combat the profibrotic effects of alcohol in MASH.
Keyphrases
  • liver fibrosis
  • high glucose
  • alcohol consumption
  • induced apoptosis
  • dendritic cells
  • drug induced
  • peripheral blood
  • nlrp inflammasome
  • oxidative stress
  • risk assessment
  • cell proliferation
  • signaling pathway
  • cell death