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Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells.

Isabelle ChareyronStefan ChristenSofia MocoArmand ValsesiaSteve LassueurLoïc DayonClaes B WollheimJaime Santo DomingoAndreas Wiederkehr
Published in: Diabetologia (2020)
We propose that metabolic changes and associated mitochondrial overactivation are early adaptations to glucose stress, and may reflect what happens as a result of poor blood glucose control. Inhibition of mitochondrial pyruvate transport reduces mitochondrial nutrient overload and allows beta cells to recover from chronic glucose stress. Graphical abstract.
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