Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells.
Isabelle ChareyronStefan ChristenSofia MocoArmand ValsesiaSteve LassueurLoïc DayonClaes B WollheimJaime Santo DomingoAndreas WiederkehrPublished in: Diabetologia (2020)
We propose that metabolic changes and associated mitochondrial overactivation are early adaptations to glucose stress, and may reflect what happens as a result of poor blood glucose control. Inhibition of mitochondrial pyruvate transport reduces mitochondrial nutrient overload and allows beta cells to recover from chronic glucose stress. Graphical abstract.