Nucleic acid sensor STING drives remodeling and its inhibition enhances steroid responsiveness in chronic obstructive pulmonary disease.
Bushra MdkhanaNarjes Saheb Sharif-AskariRakhee K RamakrishnanBaraa Khalid Al-SheaklyShirin HafeziFatemeh Saheb Sharif-AskariKhuloud BajboujQutayba HamidRabih HalwaniPublished in: PloS one (2023)
These findings support that STING pathway plays an important role in COPD pathogenesis, via inducing pulmonary inflammation, steroid resistance, and remodeling. This raises the possibility of using STING inhibitor as a potential therapeutic adjuvant in combination with common steroid treatment.