Pan-cancer landscape of CD274 (PD-L1) rearrangements in 283,050 patient samples, its correlation with PD-L1 protein expression, and immunotherapy response.
Andrew D KellyKarthikeyan MurugesanZheng KuangMeagan MontesionJeffrey S RossLee A AlbackerRichard S P HuangDouglas I LinUmut DemirciJames CreedenPublished in: Journal for immunotherapy of cancer (2021)
gene rearrangements are associated with increased PD-L1 IHC scores, higher TMB, and potential clinical benefit in ICI-treated patients with cancer.