Genetic Variability of Antioxidative Mechanisms and Cardiotoxicity after Adjuvant Radiotherapy in HER2-Positive Breast Cancer Patients.

Tanja Marinko Jakob Timotej Stojanov Konda Vita Dolzan Katja Goričar

Published in: Disease markers (2020)

In our study, polymorphisms PON1 rs662 and rs854560, CAT rs1001179, and GSTP1 rs1695 were significantly associated with the occurrence of cardiac adverse events after adjuvant RT and could serve as biomarkers contributing to treatment personalization.

Keyphrases

early stage
positive breast cancer
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
risk assessment
squamous cell carcinoma
locally advanced
combination therapy