A Systematic Review of the Pharmacokinetics and Pharmacodynamics of Novel Beta-Lactams and Beta-Lactam with Beta-Lactamase Inhibitor Combinations for the Treatment of Pneumonia Caused by Carbapenem-Resistant Gram-Negative Bacteria.

Emanuele RandoEmmanuel NovyFlavio SangiorgiGennaro De PascaleMassimo FantoniRita MurriJason A RobertsMenino Osbert Cotta

Published in: International journal of antimicrobial agents (2024)

Although lung pharmacokinetics was rarely described, this review observed high target attainment using plasma pharmacokinetic data for all novel beta-lactams. Future studies should describe lung pharmacokinetics in patient populations at risk of carbapenem-resistant pathogen infections.

Keyphrases

escherichia coli
gram negative
big data
current status
extracorporeal membrane oxygenation
artificial intelligence
smoking cessation
data analysis