Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling.

Yuming ZouMelika SaremShengnan XiangHonggang HuWeidong XuV Prasad Shastri

Published in: BMC cancer (2019)

These results indicate that MASM possesses potency against cancer cells and modulating autophagy during MASM administration could be used to further enhance its therapeutic effects.

Keyphrases

induced apoptosis
signaling pathway
endoplasmic reticulum stress
reactive oxygen species
pi k akt
oxidative stress
cell death
cell proliferation
water soluble