Stimuli-responsive spin crossover nanoparticles for drug delivery and DNA-binding studies.

Christina D PolyzouPatroula GkolfiChristos T ChasapisVlasoula BekiariAriadni ZiannaGeorge Psomas Ondřéj Malina Vassilis Tangoulis

Published in: Dalton transactions (Cambridge, England : 2003) (2022)

Aminated silica hybrid, spin-crossover (SCO) nanoparticles (AmNPs) coupled with ( S )-naproxen (NAP) were proposed for potential drug nanocarriers through drug release experiments at various pH values. DNA- and albumin-binding studies were also carried out using diverse techniques in order to investigate the interaction of the nanoparticles with calf-thymus DNA and serum albumins and to determine the corresponding binding constants.

Keyphrases

dna binding
drug delivery
drug release
single molecule
cancer therapy
transcription factor
circulating tumor
cell free
room temperature
open label
density functional theory
walled carbon nanotubes
emergency department
placebo controlled
clinical trial
molecular dynamics
electronic health record