Bovine viral diarrhea virus non-structural protein NS4B induces autophagosomes in bovine kidney cells.

Published in: Archives of virology (2018)

Bovine viral diarrhea virus (BVDV) is an important pathogen in cattle that causes economic losses in livestock industries. Autophagy is an essential cell system for the maintenance of homeostasis and is induced by various triggers, including infection by viruses. BVDV infection leads to autophagy in order to enhance its replication in cells. In this study, we investigated the effect of BVDV non-structural proteins on the induction of autophagosomes. We found that NS4B alone could induce autophagosomes, suggesting a novel and important function of NS4B in BVDV replication.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
cell cycle arrest
cell death
signaling pathway
dengue virus
sars cov
oxidative stress
candida albicans
zika virus
mesenchymal stem cells
cell therapy
irritable bowel syndrome
bone marrow
binding protein
single molecule
high speed
aedes aegypti