Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats.

Emad H M HassaneinOmnia A M Abd El-GhafarMarwa A AhmedAhmed M SayedWail M Gad-ElrabJamaan S AjaremAhmed A AllamAyman Moawad Mahmoud

Published in: Drug design, development and therapy (2020)

AV and ED prevent CP cardiotoxicity by attenuating oxidative stress and tissue injury, and modulating cytoglobin, and PI3K/Akt/mTOR and Keap1/Nrf2 signaling. Therefore, AV and ED may represent promising agents that can prevent cardiac injury in patients receiving CP.

Keyphrases

oxidative stress
emergency department
dna damage
ischemia reperfusion injury
low dose
left ventricular
diabetic rats
signaling pathway
high dose
heart failure
small molecule
heat shock