A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer.
Aesha I AliMinyu WangBianca von ScheidtPilar M DominguezAaron J HarrisonDaniela G M TantaloJian KangAmanda J OliverJack D ChanXin DuYuchen BaiBelinda LeeRicky W JohnstonePhillip K DarcyMichael H KershawClare Y SlaneyPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
We propose that patients with pancreatic cancer could be treated using a scheme that contains dual-specific CAR T cells, a vaccine that activates the dual-specific CAR T cells through their TCR, and the administration of Pano.
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