Multidrug resistant 1 (MDR1) C3435T and G2677T gene polymorphism: impact on the risk of acute rejection in pediatric kidney transplant recipients.
Mai S KorkorTarek El-DesokyYoussef M MosaadDoaa M SalahAyman HammadPublished in: Italian journal of pediatrics (2023)
The C allele, CC and CT genotypes of Multidrug resistant 1 gene (C3435T) and the T allele, GT and TT genotypes of Multidrug resistant 1 gene (G2677T) gene polymorphism may be risk factors for acute rejection and this can be attributed to their effect on tacrolimus pharmacokinetics. Tacrolimus therapy may be tailored according to the recipient genotype for better outcome.
Keyphrases
- multidrug resistant
- drug resistant
- liver failure
- gram negative
- acinetobacter baumannii
- klebsiella pneumoniae
- respiratory failure
- copy number
- drug induced
- genome wide
- aortic dissection
- genome wide identification
- computed tomography
- hepatitis b virus
- stem cells
- gene expression
- magnetic resonance
- pseudomonas aeruginosa
- contrast enhanced
- escherichia coli
- extracorporeal membrane oxygenation
- young adults
- transcription factor