Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.
José Eduardo Roa-CoriaJorge Baruch Pineda-FariasPaulino Barragán-IglesiasGeovanna Nallely Quiñonez-BastidasÁngel Zúñiga-RomeroJuan Carlos Huerta-CruzJuan Gerardo Reyes-GarcíaFrancisco Javier Flores-MurrietaVinicio Granados-SotoHector Isaac Rocha-GonzalezPublished in: BMC neuroscience (2019)
Our data suggest that H2S leads to hyperalgesia in diabetic rats through activation of TRPV1, TRPA1 and TRPC channels and, subsequent intraepidermal fibers loss. CBS enzyme inhibitors or TRP-channel blockers could be useful for treatment of painful diabetic neuropathy.