Serendipitous Synthesis of Pyridoquinazolinones via an Oxidative C-C Bond Cleavage.
Matthias BrendelPriyanka R SakhareGaurav DahiyaParthasarathi SubramanianKrishna P KaliappanPublished in: The Journal of organic chemistry (2020)
A direct one-pot copper-catalyzed oxidative C-C bond cleavage route to the synthesis of pyridoquinazolinones is described. This one-pot strategy involves a copper-catalyzed C-N coupling followed by concomitant C(sp3)-H oxidation and amidation via oxidative C-C bond cleavage under an O2 atmosphere to deliver the target molecules in high yields.