PHLPP1 deficiency protects against age-related intervertebral disc degeneration.

Changli Zhang Katherine M Joseph Nazir M Khan Martha Elena Diaz-Hernandez Hicham Drissi Svenja Illien-Jünger

Published in: JOR spine (2022)

deficiency protected against NP phenotypic changes, extracellular matrix degradation, and cell apoptosis in the process of IVD degeneration, probably through FOXO1 activation, making PHLPP1 a promising therapeutic target for treating IVD degeneration.

Keyphrases

extracellular matrix
cell proliferation
replacement therapy
transcription factor
pi k akt