TP53 mutations increase radioresistance in rhabdomyosarcoma and Ewing sarcoma.
Dana L CaseyKenneth L PitterLeonard H WexlerEmily K SlotkinGaorav P GuptaSuzanne L WoldenPublished in: British journal of cancer (2021)
Our results show that TP53 mutations are associated with increased radioresistance in RMS and ES. Novel strategies to overcome this radioresistance are important for improved outcomes in p53 disruptive RMS and ES.